Longitudinal Innate and Heterologous Adaptive Immune Responses to SARS‐CoV‐2 JN.1 in Transplant Recipients With Prior Omicron Infection: Limited Neutralization but Robust CD4 <sup>+</sup> T‐Cell Activity
These findings offer important insights into the durability and breadth of immunity following natural infection in immunocompromised transplant recipients. While heterologous neutralizing antibodies were limited, sustained CD4<sup>+</sup> T-cell responses may help mitigate severe disease following exposure to JN.1-derived variants, which continue to dominate the SARS-CoV-2 landscape.
Authors
- Atul Humar (ORCID: https://orcid.org/0000-0002-1751-7159)
- Victor H. Ferreira (ORCID: https://orcid.org/0000-0002-1472-9711)
- Alexandra Kurtesi (ORCID: https://orcid.org/0000-0002-4122-7899)
- Deepali Kumar (ORCID: https://orcid.org/0000-0003-1961-0477)
- Brandon A. Keith (ORCID: https://orcid.org/0000-0002-3395-157X)
- Victoria Hall (ORCID: https://orcid.org/0000-0001-9353-0059)
- S. Marocco
- Anne‐Claude Gingras (ORCID: https://orcid.org/0000-0002-6090-4437)
- Freda Qi (ORCID: https://orcid.org/0000-0002-2859-3667)
- Faranak Mavandadnejad
- A. Ferro
- G. Amidpour
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Toronto General Hospital (CA)
- Toronto General Hospital Research Institute
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/tid.70067
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Government of Ontario
- Canadian Institutes of Health Research