Novel thiazole–thiadiazole as a potential anti-Alzheimer agent: synthesis and molecular interactions via an in silico study
The synthesized Schiff-base derivatives, especially compound 8, demonstrated strong anti-Alzheimer and antioxidant activity. These findings suggest their potential as lead candidates for further development of multifunctional therapeutics targeting neurodegenerative disorders.
Authors
- Rafaqat Hussain (ORCID: https://orcid.org/0000-0003-4810-4776)
- Hamdy Kashtoh (ORCID: https://orcid.org/0000-0002-6377-1115)
- Magda H. Abdellattif (ORCID: https://orcid.org/0000-0002-8562-4749)
- Shoaib Khan (ORCID: https://orcid.org/0000-0001-5404-0954)
- Tayyiaba Iqbal (ORCID: https://orcid.org/0000-0003-1102-7463)
- Zanib Fiaz
Institutions
- Taif University (SA)
- Hazara University (PK)
- Abbottabad University of Science and Technology (PK)
- Yeungnam University (KR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1080/17568919.2025.2525066
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taif University