Histochemical analysis of stomach, liver and kidney tissues in local dogs following hydrochloric acid – induced acidification

Metabolic acidosis is an acid-base imbalance associated with several disorders in different organs, our study elucidate the effects of acidosis on stomach, liver and kidney in local dog by histological and histochemical. local dogs were divided into four groups: a control group and three experimental groups treated with hydrochloric acid (75 mmol), HCL (150 mmol) and HCL (300 mmol) respectively. Treatment duration was set for 15 days, with tissue samples collected for analysis.Histomorphological evaluations showed significant changes in the targeted organs architecture, including gastric sloughing, fibrosis and inflammatory cell infiltration.The hepatic tissue exhibited necrosis, dilation in portal vein and thrombosis with inflammatory cell infiltration and fibrosis. The renal tissue show glomeruli shrinkage with tubular atrophy and cystic dilation. Histochemical analysis revealed decreased PH levels , increase lactic acid levels and elevated liver enzymes with rising of serum levels of urea and creatinine, indicating cellular damage.