Assessment Of Corin Serum Level In Patients With Polycystic Ovary Syndrome A Cross-Sectional Study

Background : Polycystic ovary syndrome is one of the most common metabolic disorder in women with reproductive age group . With a prevalence rate of nearly 9% among women with reproductive age. This study aimed to evaluate the Corin serum level in patients with PCOS and its relation with insulin resistance and hyperandrogenism. Methods: 60 patients with PCOS were screened to be suitable for participation in this study aged from 19 to 45 women they have been attended to outpatients clinic as well as 30 healthy women as a control group Serum level of insulin, testosterone and Corin were estimated, using an ELISA kit, as well as glucose ,FSH,LH and HbA1c have been calculated. Results : the present study revealed that there is a significant differences in Corin serum level between PCOS patients and healthy control group. As well as it showed a decrease in the ANP levels, although Corin is part of its function, which is to activate the ANP. In addition the study demonstrated that the Plasma Corin was directly correlated with BMI and LH/FSH ratio. Conclusions: The results of this study emphasize the important role of Corin serum level in women with PCOS. Our data suggest that crculating Corin reflect the metabolic abnormalities PCOS patients. Also revealed that there was a strong positive correlation between corin level and insulin resistance.