First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in a protein-enriched saline solution. For the studied conditions of dose, dose rate and linear energy transfer (LET), UHDR irradiation showed comparable efficacy to SDR in pancreatic cancer cell killing in vitro, along with inducing a similar tumor growth delay in vivo. These findings emphasize the potential of high-LET UHDR irradiation and support further investigation of oxygen ions at UHDR.

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Publication Details

Journal
Physics and Imaging in Radiation Oncology
Published
2025-07-01
DOI
https://doi.org/10.1016/j.phro.2025.100803
Citations
1
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
1.52

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article

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Stephan Brons, Nora Schuhmacher, R. Cee, Thomas Tessonnier et al.
1 citations
Physics and Imaging in Radiation Oncology
Radiation Therapy and Dosimetry
1.52
article

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Stephan Brons, Nora Schuhmacher, R. Cee, Thomas Tessonnier, Ivana Đokić, Mahdi Akbarpour, Amir Abdollahi, Jürgen Debus, Christian Schömers, Thomas Haberer, Mahmoud Moustafa, Kristoffer Petersson, Stefan Scheloske, Andrea Mairani, Domenico Ivan Filosa, Celine Karle
article en
1 citations

Abstract

Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in a protein-enriched saline solution. For the studied conditions of dose, dose rate and linear energy transfer (LET), UHDR irradiation showed comparable efficacy to SDR in pancreatic cancer cell killing in vitro, along with inducing a similar tumor growth delay in vivo. These findings emphasize the potential of high-LET UHDR irradiation and support further investigation of oxygen ions at UHDR.

Physics and Imaging in Radiation OncologyVol. 35
Suez Canal University (EG), German Cancer Research Center (DE), Heidelberg University (DE), University Hospital Heidelberg (DE), University of Oxford (GB), Heidelberger Institut für Radioonkologie (DE), National Center for Oncological Hadrontherapy (IT), CRUK/MRC Oxford Institute for Radiation Oncology (GB), National Center for Tumor Diseases (DE)
Nationales Centrum für Tumorerkrankungen Heidelberg, National Institutes of Health
Openalex Percentile: Top 17%
Radiation Therapy and Dosimetry
1.52
DOIOpen Access PDFOpenAlex
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