Efficacy and safety of narlumosbart, an anti-RANKL monoclonal antibody, in postmenopausal women with osteoporosis: a multi-center, randomized, double-blind, placebo- and active-controlled, phased II study
This study was supported by Shanghai JMT-Bio Technology Co., Ltd.; National Key R&D Program of China [2021YFC2501700]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-1-002]; National High Level Hospital Clinical Research Funding [2022-PUMCH-D-006]; the National Natural Science Foundation of China [No. 82270938, No. 81970757]; and the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2023-PT320-10].
Authors
- Weibo Xia
- Difei Wang (ORCID: https://orcid.org/0000-0002-9711-8501)
- Shuang Yan (ORCID: https://orcid.org/0000-0001-6439-0122)
- Qun Cheng (ORCID: https://orcid.org/0000-0001-5604-1504)
- Baofang Yang
- Zhufeng Wu
- Jing Yuan (ORCID: https://orcid.org/0000-0002-8937-9568)
- Hongmei Li (ORCID: https://orcid.org/0000-0001-9483-2964)
- Di Wang (ORCID: https://orcid.org/0000-0002-6221-0949)
- Man Li (ORCID: https://orcid.org/0000-0002-3839-0281)
- Yukun Li (ORCID: https://orcid.org/0000-0003-3576-8047)
- Xueyuan Zhang (ORCID: https://orcid.org/0000-0003-0159-6996)
- Ying Xing (ORCID: https://orcid.org/0000-0003-1424-3612)
- Hui Sheng (ORCID: https://orcid.org/0000-0002-2040-8842)
- Bing Song (ORCID: https://orcid.org/0009-0002-4426-2419)
- Cai H (ORCID: https://orcid.org/0000-0002-9386-5286)
- Yujin Ma (ORCID: https://orcid.org/0000-0003-2054-3398)
- Lin Shen (ORCID: https://orcid.org/0000-0003-2392-3353)
- Yue Chi (ORCID: https://orcid.org/0009-0002-7337-9982)
- Weiping Lu (ORCID: https://orcid.org/0000-0003-0737-1958)
- Yuhong Zeng (ORCID: https://orcid.org/0000-0002-8805-0066)
- Mei Zhu (ORCID: https://orcid.org/0000-0002-6313-153X)
- Mei Cheng
Institutions
- Hebei Medical University (CN)
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Third Hospital of Hebei Medical University (CN)
- Huaian First People’s Hospital (CN)
- Xi'an Honghui Hospital (CN)
- Huadong Hospital (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Wuhan Union Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Shijiazhuang Yiling Pharmaceutical (China) (CN)
- Qilu Hospital of Shandong University (CN)
- First Hospital of Xi'an (CN)
- Union Hospital (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
- Jinzhou Medical University (CN)
- Qiqihar Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- EClinicalMedicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.eclinm.2025.103329
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital