Drug-induced fluorosis: A study based on the national and international pharmacovigilance databases
This study highlights pharmacovigilance signals suggesting a potential association between fluorosis and certain fluorinated compounds, particularly sodium fluoride, voriconazole, fluconazole, fludarabine and ciprofloxacin. Among these, only sodium fluoride and voriconazole include fluorosis in the summary of product characteristics. Clinicians should remain vigilant regarding this potential adverse drug reaction, especially with long-term use of these medications.
Authors
- Marie Briet (ORCID: https://orcid.org/0000-0003-3738-5998)
- François Parant (ORCID: https://orcid.org/0000-0002-4019-532X)
- G. Veyrac
- Bénédicte Lelièvre
- Joëlle Michot
- Christine Le Beller
- Véronique Pizzoglio
- Delphine Bourneau‐Martin (ORCID: https://orcid.org/0000-0003-4103-7558)
- Myriam Mellou
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon College (US)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Biologie et Modélisation de la Cellule (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Université d'Angers (FR)
Publication Details
- Journal
- Therapies
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.therap.2025.06.006
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00