Neurobiological and Functional Outcomes of the Interpersonal Whole-Brain Model of Care in Autism Spectrum Disorder: A Mixed-Methods Study

The Interpersonal Whole-Brain Model of Care (IWBMC™) presents a comprehensive intervention for autism spectrum disorder (ASD) targeting neurobiological frameworks. This mixed-methods study evaluated its efficacy through QEEG connectivity analysis of a longitudinal case study and pre-post outcomes from 61 ASD clients. Results demonstrated normalization of brain connectivity patterns alongside statistically significant improvements with large effect sizes across behavioral regulation (d=1.26), emotional recognition (d=0.98), cognitive functioning (d=0.84), and neurophysiological integration (d=1.52). The concurrent improvement in brain connectivity and functional outcomes suggests that the IWBMC™’s integrated approach effectively addresses both neurological underpinnings and behavioral manifestations of ASD, offering promising pathways for intervention.