Platinum plus etoposide with durvalumab for extensive-stage small-cell lung cancer with untreated brain metastases: a multicenter, single-arm phase II trial (LOGiK2001, SPEED)
Durvalumab combined with platinum-etoposide chemotherapy demonstrated promising intracranial activity in SCLC patients with untreated brain metastases. However, only a small proportion of patients achieved a sustained response, highlighting the need for regular monitoring of brain metastases.
Authors
- Hidenobu Ishii
- Yoshimasa Shiraishi (ORCID: https://orcid.org/0000-0001-5015-193X)
- M. Izumi
- Ryotaroh Morinaga
- Satoshi Iyama (ORCID: https://orcid.org/0000-0002-6328-494X)
- Shinsuke Tsumura (ORCID: https://orcid.org/0000-0001-9813-9761)
- Keiji Mizuno
- Eiji Iwama (ORCID: https://orcid.org/0000-0001-8252-290X)
- Yuko Tsuchiya‐Kawano
- Kohei Otsubo (ORCID: https://orcid.org/0000-0002-9476-8840)
- Yuta Yamanaka (ORCID: https://orcid.org/0009-0009-7872-4395)
- Takayuki Shimose
- Masayuki Oki (ORCID: https://orcid.org/0000-0003-4638-1569)
- Isamu Okamoto (ORCID: https://orcid.org/0000-0002-7587-6096)
- Kentaro Ito (ORCID: https://orcid.org/0000-0001-5461-9894)
- Kazunori Tobino (ORCID: https://orcid.org/0000-0002-3456-6833)
- Haruko Daga (ORCID: https://orcid.org/0000-0002-5191-6233)
- S. Miura
- Y. Misumi
- Yukihiro Toi (ORCID: https://orcid.org/0000-0001-5983-3531)
- Hiroto Inoue
- Katsuhiko Naoki (ORCID: https://orcid.org/0000-0002-9637-1388)
- Hirokazu Taniguchi (ORCID: https://orcid.org/0000-0003-4212-4776)
- Yuh Sakata
- Hiroki Mizutani
- Takeshi Harada
- Saori Omori
Institutions
- Kurume University (JP)
- Kagoshima University (JP)
- Kansai Medical University (JP)
- Kyushu University (JP)
- Oita University (JP)
- Kyushu Economic Research Center (JP)
- Fukuoka University Hospital (JP)
- Niigata Cancer Center Hospital (JP)
- Saiseikai Kumamoto Hospital (JP)
- Osaka City General Hospital (JP)
- Omuta hospital (JP)
- Kitasato University Hospital (JP)
- Kyushu Hospital (JP)
- Oita Prefectural Hospital (JP)
- Kumamoto University Hospital (JP)
- Saitama Cancer Center (JP)
- Kitakyushu Municipal Medical Center (JP)
- Japan Community Healthcare Organization (JP)
- Aso Iizuka Hospital (JP)
- Nagoya Medical Center (JP)
- Soka Municipal Hospital (JP)
- Nagasaki University Hospital (JP)
- Kumamoto Medical Center (JP)
- Sendai Kousei Hospital (JP)
- Kitasato University (JP)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105325
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Taiho Pharmaceutical
- Novocure
- Merit Medical Systems
- Astellas Pharma
- Shionogi
- Ono Pharmaceutical
- Novartis Pharma
- Chugai Pharmaceutical
- Daiichi Sankyo Europe