Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation
Beyond serving as a preclinical platform for anti-infective therapies, the model provides actionable insights into optimizing human prosthetic biomechanics, such as reducing stress shielding through FEA-informed design principles. The 3D printing workflow further demonstrates rapid prototyping capabilities for patient-specific orthopaedic implants.
Authors
- Yejun Zha (ORCID: https://orcid.org/0000-0001-7124-2128)
- Hao Wang (ORCID: https://orcid.org/0000-0001-8666-6900)
- Tingting Fan (ORCID: https://orcid.org/0009-0005-5548-4174)
- Xieyuan Jiang (ORCID: https://orcid.org/0000-0002-2993-1357)
- Hao Sun
- Shijie Fan (ORCID: https://orcid.org/0000-0001-6197-2637)
- Jialin Hu
- Honghu Xiao
- Haoran Zhang (ORCID: https://orcid.org/0000-0002-3283-5630)
- Yilong He (ORCID: https://orcid.org/0009-0001-9815-4141)
- Heng Liu (ORCID: https://orcid.org/0000-0001-7563-2676)
- Shuai Lü (ORCID: https://orcid.org/0000-0002-0169-349X)
- Qi Gu (ORCID: https://orcid.org/0000-0001-8709-2865)
- Rui Yuan (ORCID: https://orcid.org/0000-0003-4837-6018)
- Yong Huan
- Maoqi Gong (ORCID: https://orcid.org/0009-0008-1699-4835)
- Daqiang Sun (ORCID: https://orcid.org/0000-0003-2222-4657)
- C. Wei (ORCID: https://orcid.org/0009-0001-8662-2657)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Beijing Emergency Medical Center (CN)
- Beijing Institute of Neurosurgery (CN)
- Institute of Mechanics (CN)
- University of Chinese Academy of Sciences (CN)
- Institute of Zoology (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.jot.2025.05.007
- Citations
- 2
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01