Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis
SIRT3 regulates ferroptosis by inhibiting excessive mitophagy in osteoblasts, providing a novel mechanistic pathway for mitigating GIOP. These findings suggest that SIRT3 represents a critical regulator of mitophagy-dependent ferroptosis and a potential therapeutic target for GIOP.
Authors
- Zhenqiu Chen (ORCID: https://orcid.org/0000-0002-2548-1301)
- Yinuo Fan
- Hanjun Fang (ORCID: https://orcid.org/0000-0002-7125-6404)
- Benlu Chen
- Yanwen Zhou (ORCID: https://orcid.org/0000-0003-3636-0123)
- Mengyu Jiang (ORCID: https://orcid.org/0000-0001-6898-5967)
- Shihua Gao (ORCID: https://orcid.org/0000-0003-4143-3067)
- Yuhao Liu (ORCID: https://orcid.org/0000-0002-0447-6677)
- Zhiwen Chen (ORCID: https://orcid.org/0000-0001-9535-2030)
- Ziyuan Li (ORCID: https://orcid.org/0000-0001-8029-9804)
- Zeqing Huang (ORCID: https://orcid.org/0000-0002-7576-1408)
- Chi Zhou (ORCID: https://orcid.org/0000-0003-1905-9494)
- Yue Hu (ORCID: https://orcid.org/0000-0001-8567-698X)
- Hongduo Lu (ORCID: https://orcid.org/0009-0004-3913-4855)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangzhou University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1097/js9.0000000000002783
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11