EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation (Adv. Sci. 25/2025)
Extrachromosomal circular DNaIn article number 2501934, Bin Shi, Shuyu Zhang, and co-workers present the increased existence of eccDNA induced by ionizing radiation.VPS41 gene in the eccDNA confers protection against genotoxic stress.This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to genotoxic stress.
Authors
- Hui Qiao (ORCID: https://orcid.org/0000-0002-9242-2205)
- Bin Song (ORCID: https://orcid.org/0000-0002-5227-6696)
- Jinchen He (ORCID: https://orcid.org/0009-0003-2645-5513)
- Wen‐Jun Tu (ORCID: https://orcid.org/0000-0002-1703-1802)
- Ping Yang (ORCID: https://orcid.org/0000-0002-5823-7620)
- Tao Yan (ORCID: https://orcid.org/0000-0002-1217-3705)
- Hao Bai (ORCID: https://orcid.org/0000-0002-5738-4186)
- Qian Li (ORCID: https://orcid.org/0000-0001-8827-939X)
- Shuyu Zhang (ORCID: https://orcid.org/0000-0003-1419-3635)
- Yining Zhang (ORCID: https://orcid.org/0000-0002-8750-795X)
- Fengdi Jiang (ORCID: https://orcid.org/0009-0002-9773-1709)
- Daojiang Yu
- Bin Shi (ORCID: https://orcid.org/0000-0003-4214-6940)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/advs.202570197
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00