Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging
Overall, our findings revealed a mechanism by which NMN-sEVs attenuated mitochondrial dysfunction and rescued cellular senescence by promoting NAD<sup>+</sup>/SIRT3 pathway-mediated mitophagy and might provide a promising strategy for anti-aging pharmaceuticals.
Authors
- Jiali Li (ORCID: https://orcid.org/0000-0001-6356-627X)
- Zixuan Sun (ORCID: https://orcid.org/0000-0002-7789-6509)
- Yulin Tan (ORCID: https://orcid.org/0000-0002-3278-7624)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0002-5392-9468)
- Xuezhong Xu (ORCID: https://orcid.org/0000-0001-9232-3381)
- Wei Ding (ORCID: https://orcid.org/0000-0003-2457-4597)
- Zin‐An Wu (ORCID: https://orcid.org/0000-0001-8466-7678)
- Wenhuan Bai
- Yong Zheng
- Hui Qian (ORCID: https://orcid.org/0000-0002-2611-2946)
- Xinyi Deng (ORCID: https://orcid.org/0000-0001-5994-5832)
Institutions
- Jiangsu University (CN)
- Zhanjiang Experimental Station (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13287-025-04460-w
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions