Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study
There was no association between early beta-blocker exposure and the primary outcome which was blood-based brain injury biomarker levels on day 3. In exploratory analysis, we found that early beta-blocker may associated with decreased NSE level on day 14. Due to the retrospective nature of the study and the use of propensity-weighted analysis to identify associations, direct clinical practice changes cannot be recommended. However, the significant association with NSE level warrants further investigation through prospective studies or randomized controlled trials to confirm the potential neuroprotective effect of early beta-blocker exposure on neuronal cellular injury.
Authors
- Jason Barber (ORCID: https://orcid.org/0000-0002-3016-7800)
- Joseph P. Mathew (ORCID: https://orcid.org/0000-0002-3815-4131)
- Adrian F. Hernandez (ORCID: https://orcid.org/0000-0003-3387-9616)
- Jordan Hatfield (ORCID: https://orcid.org/0000-0003-3336-7258)
- Miriam M. Treggiari (ORCID: https://orcid.org/0000-0003-4639-3682)
- Jordan Komisarow (ORCID: https://orcid.org/0000-0003-3919-7931)
- Ramesh Grandhi (ORCID: https://orcid.org/0000-0001-9000-6083)
- Michael L. James (ORCID: https://orcid.org/0000-0002-8715-5210)
- Joseph Miller (ORCID: https://orcid.org/0000-0002-9451-1359)
- Tetsu Ohnuma (ORCID: https://orcid.org/0000-0002-2303-6802)
- Nancy Temkin
- Vijay Krishnamoorthy (ORCID: https://orcid.org/0000-0002-1365-4121)
- Geoffrey A. Manley (ORCID: https://orcid.org/0000-0002-4950-4651)
- Pattrapun Wongsripuemtet (ORCID: https://orcid.org/0000-0003-3301-3214)
- Daniel T. Laskowitz (ORCID: https://orcid.org/0000-0003-3430-8815)
- Karthik Raghunathan (ORCID: https://orcid.org/0000-0003-2809-5374)
- Nophanan Chaikittisilpa (ORCID: https://orcid.org/0000-0002-4210-8066)
- Cina Sasannejad
- Ben Goldstein
- Monica S. Vavilala
- Katharine Colton
Institutions
- Siriraj Hospital (TH)
- Henry Ford Health System (US)
- Duke University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- University of Utah (US)
- Mahidol University (TH)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of the Intensive Care Society
- Published
- 2025-06-29
- DOI
- https://doi.org/10.1177/17511437251349680
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health