Modulation of Wnt/β‐Catenin Signaling by <scp>STAT3</scp> Inhibition Restores Myogenic Capacity in Sarcopenia
STAT3 impairs myogenic proliferation and differentiation by negatively regulating the Wnt/β-catenin pathway, contributing to sarcopenia progression. Targeting STAT3 may serve as a promising therapeutic strategy for restoring muscle regeneration and function in sarcopenia.
Authors
- Dianfu Zhang
- Xin Tao (ORCID: https://orcid.org/0000-0002-4246-0131)
- Yue Li (ORCID: https://orcid.org/0000-0002-1898-9027)
- Minghui Fu (ORCID: https://orcid.org/0000-0002-1991-3497)
- Suhong Zhang (ORCID: https://orcid.org/0000-0001-8821-0843)
- Guo-Fen Tu
- Liping Yin
Institutions
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1111/1756-185x.70340
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Government of Jiangsu Province