Depressive Symptoms and Osteoporosis in Middle-Aged and Older Adults: A Cross-Sectional Analysis of NHANES and HRS Data
Depressive symptoms (PHQ-9/CES-D8) significantly associate with higher osteoporosis risk in older adults, with consistent cross-sectional findings across populations. While causality remains unclear, results support clinical bone density monitoring in depression care and depression screening in osteoporosis management. Future longitudinal studies should clarify mechanisms, while public health strategies should integrate mental-bone health prevention approaches.
Authors
- Xinyu Hu (ORCID: https://orcid.org/0000-0002-7659-6619)
- Kai Cheng (ORCID: https://orcid.org/0000-0001-6303-015X)
- Lei Chen (ORCID: https://orcid.org/0000-0003-3476-0035)
- Zhongyi Zhang (ORCID: https://orcid.org/0000-0002-8758-1949)
- Peijian Tong (ORCID: https://orcid.org/0000-0003-1647-1934)
- Jiaju Zhou
- Wen Zhang
- Yi Tang (ORCID: https://orcid.org/0009-0000-5525-5244)
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Provincial Hospital of TCM (CN)
Publication Details
- Journal
- Geriatric Orthopaedic Surgery & Rehabilitation
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1177/21514593251357525
- Citations
- 2
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- National Natural Science Foundation of China