Towards individualised treatment of urinary tract infections
Monitoring host- and pathogen-specific biomarkers alongside drug levels at the site of infection offers promise for personalised antimicrobial therapy. Here, we highlight the potential of longitudinally monitoring biomarkers in urine using existing technologies to enable individualised PK-PD optimisation in urinary tract infections. Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.
Authors
- Ellen V Stadler (ORCID: https://orcid.org/0000-0002-8208-8434)
- Alison Holmes (ORCID: https://orcid.org/0000-0001-5554-5743)
- Timothy M. Rawson (ORCID: https://orcid.org/0000-0002-2630-9722)
- Danny O’Hare
Institutions
- University of Liverpool (GB)
- Imperial College Healthcare NHS Trust (GB)
- National Institute for Health and Care Research (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1038/s43856-025-00962-z
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Warwick
- Imperial College London