Construction of a prostate adenocarcinoma molecular classification: integrating spatial transcriptomics with retrospective cohort validation
We successfully constructed MDPC with validated prognostic prediction value. This classification system provided clinicians with an effective tool to stratify PRAD patients, identifying high-risk individuals, recognizing patients prone to develop bone metastasis, and offering opportunities for early intervention to improve patients' prognosis.
Authors
- Keqin Dong (ORCID: https://orcid.org/0000-0002-2783-1635)
- Yuntao Yao (ORCID: https://orcid.org/0009-0001-4057-9470)
- Junzhe He
- Xiuwu Pan (ORCID: https://orcid.org/0000-0001-5268-0886)
- Guo Ji (ORCID: https://orcid.org/0000-0001-6060-4066)
- Bolin Zhu (ORCID: https://orcid.org/0000-0002-6846-566X)
- Xinming Cui (ORCID: https://orcid.org/0009-0007-5571-7104)
- Xingang Cui (ORCID: https://orcid.org/0000-0002-0920-9439)
- Yang Zhao (ORCID: https://orcid.org/0000-0001-6984-1770)
- Yifan Liu (ORCID: https://orcid.org/0000-0003-0516-1922)
- Zhou Wang (ORCID: https://orcid.org/0000-0002-1604-4767)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0424-8348)
- Jiaying Shi
- Runzhi Huang (ORCID: https://orcid.org/0000-0002-3221-7293)
- Bing-Nan Lu
- Yuanan Li
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Tongren Hospital (CN)
- Botswana Geoscience Institute (BW)
- Heilongjiang Provincial Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s12967-025-06661-6
- Citations
- 3
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.42