Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma
CAF-derived IL-6 drives paracrine activation of the IL6/JAK/STAT3 signaling pathway which is enriched in ILC. This leads to the acquisition of pro-tumorigenic phenotypes, highlighting the pathway as a potential therapeutic target in ILC.
Authors
- Jingjing Guo (ORCID: https://orcid.org/0000-0002-4632-4364)
- Valerie G. Brunton (ORCID: https://orcid.org/0000-0002-7778-8794)
- Elizabeth Morrow (ORCID: https://orcid.org/0000-0001-8083-626X)
- Xue Xiao (ORCID: https://orcid.org/0000-0001-7820-6920)
- Laura Gómez-Cuadrado (ORCID: https://orcid.org/0000-0002-4754-2582)
- Valeria Poli (ORCID: https://orcid.org/0000-0002-3739-3966)
- Zeanap Mabruk
- Lidia Avalle (ORCID: https://orcid.org/0000-0002-5060-633X)
- Sana Shabbir (ORCID: https://orcid.org/0009-0003-9060-0025)
- Giovana Carrasco (ORCID: https://orcid.org/0000-0002-0382-4334)
- Esme Bullock
- Adelaide I.J. Young (ORCID: https://orcid.org/0000-0002-5714-0501)
- Julia M. Houthuijzen (ORCID: https://orcid.org/0000-0003-0404-1961)
- E. Elizabeth Patton (ORCID: https://orcid.org/0000-0002-2570-0834)
- Jos Jonkers (ORCID: https://orcid.org/0000-0002-9264-9792)
- Richard Iggo (ORCID: https://orcid.org/0000-0002-8822-9111)
- Joanne Edwards (ORCID: https://orcid.org/0000-0002-7192-6906)
- Jana Trávníčková (ORCID: https://orcid.org/0000-0002-8339-9162)
- Kathryn A.F. Pennel (ORCID: https://orcid.org/0000-0003-0186-1331)
- Xuan Zhu (ORCID: https://orcid.org/0000-0003-3239-3171)
- Elizabeth Mallon
- Pim Kloosterman
- Aleksandra Rozyczko
- Ifigenia Tsoupi
Institutions
- University of Electronic Science and Technology of China (CN)
- Université de Bordeaux (FR)
- Inserm (FR)
- Edinburgh Cancer Research (GB)
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
- Institut Bergonié (FR)
- Queen Elizabeth University Hospital (GB)
- Institute of Genetics and Cancer (GB)
- Universidad de Burgos (ES)
- University of Turin (IT)
- University of Glasgow (GB)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1186/s13058-025-02074-x
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Melanoma Research Alliance
- Wellcome Trust
- Cancer Research UK
- Rosetrees Trust
- Medical Research Council
- Institute of Genetics