Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice.
Our findings indicate that both BMCM enriched with EVs and the administration of AT-MSCs and BM-MSCs effectively induced spermatogenesis in mice with busulfan-induced azoospermia. Specifically, BM-MSC therapy exhibited superior outcomes compared to AT-MSCs and BMCM alone. This study highlights the potential of EV-based therapies, particularly BMCM, as a promising strategy for treating non-obstructive azoospermia. Furthermore, the interaction of key exosome factors with critical receptors enhances our understanding of the underlying molecular mechanisms involved in restoring reproductive function in testes.
Authors
- Ali Arabi Monfared (ORCID: https://orcid.org/0000-0002-1446-5015)
- Nadiar Maratovich Mussin (ORCID: https://orcid.org/0000-0003-3600-8840)
- Arezoo Khoradmehr (ORCID: https://orcid.org/0000-0001-7460-1616)
- Alireza Afshar
- Amin Tamadon (ORCID: https://orcid.org/0000-0002-0222-3035)
- Farhad Rahmanifar (ORCID: https://orcid.org/0000-0001-9585-7266)
- Mohammad Reza Dorvash
- Afshin Zare (ORCID: https://orcid.org/0000-0002-1932-8773)
- Rano Zhankina (ORCID: https://orcid.org/0000-0001-6170-4325)
- Omid Koohi Hosseinabadi
- Nader Tanideh (ORCID: https://orcid.org/0000-0002-0643-3638)
- Asset Askerovich Kaliyev (ORCID: https://orcid.org/0000-0003-4594-4104)
- Shahrokh Zare (ORCID: https://orcid.org/0000-0002-4395-7844)
- Ulanbek Zhanbyrbekuly
Institutions
- Shiraz University (IR)
- Shiraz University of Medical Sciences (IR)
- Biotechnology Research Center (IR)
- Astana Medical University (KZ)
- Bushehr University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-14
- DOI
- https://doi.org/10.22074/ijfs.2024.2021445.1619
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royan Institute