SOME ASPECTS OF THE CREATION OF TISSUE ENGINEERING CONSTRUCTS IN ACCORDANCE WITH THE FEATURES OF THE PATHOGENESIS OF A BURN WOUND: LITERATURE REVIEW

Highlights For the treatment of skin wounds, it is important to create biomedical tissue engineering constructs in accordance with the features of the pathogenesis of the wound process. The article describes the issues of antibacterial protection and wound cleansing, as well as the principles of creation and the basic requirements for skin equivalents. Abstract Man-made disasters related to mining are often accompanied by polytrauma, characterized by burn and chemical injury to the skin of varying degrees. Currently, tissue engineering approaches are actively developing in the field of biomedical constructs, which are characterized by the use of autologous and allogeneic cells and extracellular matrix proteins, as well as various biocompatible materials acting as a cellular carrier. Therefore, it is possible to create skin equivalents that can act as effective wound healing agents, taking into account the depth of the lesion. This review examines the approach to creating tissue engineering constructs for the treatment of skin burn injuries in accordance with the features of the pathogenesis of the wound process. The article describes the issues of antibacterial protection and aspects of cleansing necrotic tissues, as well as the principles of creation and the basic requirements for skin equivalents.