Optimization of Bronchodilator Treatment in COPD: A Comparison of the Glycopyrrolate/Formoterol Combination vs. Formoterol Alone

Background: Using a glycopyrrolate/formoterol combination to manage COPD patients is considered a new method. The objectives of this study are to evaluate the effectiveness of the glycopyrrolate/formoterol combination against formoterol alone in optimizing lung function in moderate and severe COPD patients.Methods: Twenty patients with chronic obstructive pulmonary disease were of class II and III according to the ASA classification. Patients were prospectively divided into two groups: group 1 was given glycopyrrolate and formoterol metered dose inhalers, and group 2 was given a formoterol nebulizer alone. Optimization of treatment was assessed on the first day, at the second week, and at the fourth week by lung function tests (FEV1 and FVC).Results: Formoterol alone and a combination of formoterol with glycopyrrolate were well tolerated and optimized lung function. FEV1, FVC, and FEV1/FVC ratio significantly increased (p value<0.001). However, the combination of glycopyrrolate and formoterol had a better effect on lung function (FEV1 and FVC) in comparison to formoterol alone (p value<0.001) in 4 weeks of use.Conclusion: Glycopyrrolate/formoterol metered dose inhaler is more effective in the optimization of the condition of patients with COPD disease than a formoterol nebulizer alone.