Periapical lesions: Assessment of clinical diagnostic accuracy and prevalence of nonendodontic lesions mimicking endodontic pathoses

Despite the high overall diagnostic accuracy, the specificity of recognizing nonendodontic periapical lesions is relatively low. Clinicians often overdiagnose endodontic lesions clinically. In the presence of periapical lesions with a diameter of 2 cm or more, clinical swelling or a nonrounded radiographic appearance, clinicians should consider the possibility of nonendodontic lesions. Diverse benign and malignant conditions can mimic endodontic pathoses. Tissue biopsy is indispensable for accurate and timely management.