Characteristics of Cerebral Cortical Structural Alterations in Female Patients with Systemic Lupus Erythematosus Without Major Neuropsychiatric Manifestations Accompanied by Anxiety and Depression
Our findings demonstrate that SLE patients presenting with anxiety and/or depression exhibit distinct neuroanatomical alterations, even without prominent neuropsychiatric manifestations. These morphological changes may represent the neurobiological substrate underlying the heterogeneous clinical spectrum of neuropsychiatric SLE (NPSLE), potentially serving as early neuroimaging biomarkers. Furthermore, these findings provide a structural framework for future studies investigating the causal relationships between these anatomical changes and the neurophysiological mechanisms underlying NPSLE.
Authors
- Shu Li (ORCID: https://orcid.org/0000-0002-7407-7217)
- Ruotong Zhao (ORCID: https://orcid.org/0009-0008-4418-7651)
- Zhicheng Liu (ORCID: https://orcid.org/0009-0006-3419-6656)
- Yifan Yang (ORCID: https://orcid.org/0000-0001-5461-7741)
- Jian Xu (ORCID: https://orcid.org/0000-0003-1612-561X)
- Yuqi Cheng (ORCID: https://orcid.org/0000-0003-4574-7063)
- Shuang Liu (ORCID: https://orcid.org/0000-0002-7961-910X)
- Guofang Zhang (ORCID: https://orcid.org/0009-0004-1189-7949)
- Ru Bai (ORCID: https://orcid.org/0000-0003-0815-4082)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Hangzhou Seventh Peoples Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-06-24
- DOI
- https://doi.org/10.31083/jin36382
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- Kunming Medical University
- Recruitment Program of Global Experts
- National Ten Thousand Talent Program
- NIH Clinical Center