Amygdalin and magnesium ions exert synergistic effects on cartilage regeneration by inhibiting chondrocyte ferroptosis via the IL-17/GPX4 axis
In the present study, we showed that IL-17A may represent a promising therapeutic target for cartilage repair and regeneration. A conservative therapeutic strategy involving joint injections of AMD (a natural plant extract) and Mg<sup>2+</sup> (a crucial endogenous factor that promotes chondrogenesis) facilitated effective cartilage repair and regeneration. This strategy represents a cost-effective approach with potential for clinical application.
Authors
- Jiangyuan Liu (ORCID: https://orcid.org/0000-0001-5808-9974)
- Houfu Ling
- Hongting Jin
- Yiwen Yang
- Hanting Xia
- Jinjin Ma
- Zhengsheng Bao
- Yichen Lu
- Taotao Xu (ORCID: https://orcid.org/0000-0002-2697-1484)
- Shuyan Zhang (ORCID: https://orcid.org/0000-0002-1653-6809)
- Xing Zhou (ORCID: https://orcid.org/0000-0002-6931-2518)
- Xuefei Zhao
- Tianyou Ma (ORCID: https://orcid.org/0009-0002-2558-1254)
- Huihui Xu (ORCID: https://orcid.org/0000-0001-7770-7600)
- Peijian Tong (ORCID: https://orcid.org/0000-0003-1647-1934)
- Zhefei Xie
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Zhejiang Chinese Medical University (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.jot.2025.05.006
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province