SYSTEMATIC REVIEW ON CARDIO-PROTECTIVE EFFECT OF HERBS/NATURALCOMPOUNDS IN DOXORUBICIN TOXICITY

This study aimed to assess the possible effect of various natural compounds against cardiotoxicity caused by doxorubicin. In accordance with the PRISMA guidelines, an extensive and recent search was performed across various electronic databases, such as Web of Science, Scopus and PubMed. A total of 25 out of 27 studies were screened according to the predetermined inclusion and exclusion criteria, leading to the identification of 06 eligible articles for this systematic review. The study observed that doxorubicin treatment decreases cell viability and enhances mortality. Co-administration of natural compounds showed protective effects, reversing these harmful outcomes caused by doxorubicin. Furthermore, doxorubicin also dramatically changed biochemical parameters and caused histological alterations in cardiac tissue, but co-treatment almost completely reverted these changes, bringing them nearer to control values. The results indicated that natural herbs protect against doxorubicininduced cardiotoxicity by their antioxidant and anti-inflammatory effects.