Dose-response mapping of bladder and rectum in prostate cancer patients undergoing radiotherapy with and without baseline toxicity correction
DRM without baseline correction appears more sensitive to high-risk subregions due to higher event counts. Non-linear toxicity grading and multivariable analysis may enhance DRM reliability.
Authors
- Jane Shortall (ORCID: https://orcid.org/0000-0002-9672-7671)
- Tanuj Puri (ORCID: https://orcid.org/0000-0002-9273-8226)
- Marcel van Herk (ORCID: https://orcid.org/0000-0001-6448-898X)
- Eliana Vásquez Osorio (ORCID: https://orcid.org/0000-0003-0741-994X)
- Peter Hoskin
- Alan McWilliam (ORCID: https://orcid.org/0000-0002-7344-2868)
- B. Avuzzi (ORCID: https://orcid.org/0000-0002-7135-4506)
- Adam Webb (ORCID: https://orcid.org/0000-0002-6699-0479)
- Ananya Choudhury (ORCID: https://orcid.org/0000-0001-9847-8165)
- Jenny C. Chang (ORCID: https://orcid.org/0000-0002-0890-9302)
- Ana Vega (ORCID: https://orcid.org/0000-0002-7416-5137)
- Liv Veldeman (ORCID: https://orcid.org/0000-0002-0995-2687)
- D. Azria (ORCID: https://orcid.org/0000-0002-7533-2988)
- Barry S. Rosenstein (ORCID: https://orcid.org/0000-0002-3149-3237)
- Alison M. Dunning (ORCID: https://orcid.org/0000-0001-6651-7166)
- Eliana Gioscio (ORCID: https://orcid.org/0009-0007-8692-7593)
- T. Rancati (ORCID: https://orcid.org/0000-0002-7849-603X)
- Maarten Lambrecht (ORCID: https://orcid.org/0000-0002-8746-2691)
- Petra Seibold (ORCID: https://orcid.org/0000-0001-7360-6335)
- Catharine West (ORCID: https://orcid.org/0000-0002-0839-3449)
- Marie‐Pierre Farcy‐Jacquet (ORCID: https://orcid.org/0009-0001-1472-2579)
- Elena Sperk (ORCID: https://orcid.org/0000-0002-8771-8124)
- Andrew Green (ORCID: https://orcid.org/0000-0002-8297-0953)
- Andrew P. Morris
- C. Talbot
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0002-1214-3557)
Institutions
- European Bioinformatics Institute (GB)
- University of Leicester (GB)
- German Cancer Research Center (DE)
- Medical College of Wisconsin (US)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Maastricht University Medical Centre (NL)
- Ghent University Hospital (BE)
- University Hospital Heidelberg (DE)
- University of Manchester (GB)
- Maastricht University (NL)
- Mount Sinai Hospital (US)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Fundación Pública Galega de Medicina Xenómica (ES)
- The Christie NHS Foundation Trust (GB)
- Bioinformatics Institute (RU)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Instituto de Investigación Sanitaria de Santiago (ES)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Maastro Clinic (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Physics and Imaging in Radiation Oncology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1016/j.phro.2025.100805
- Citations
- 2
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Eli Lilly and Company
- AstraZeneca
- Movember Foundation
- BeiGene
- National Institute for Health and Care Research
- Prostate Cancer UK
- European Commission
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Manchester Biomedical Research Centre
- Instituto de Salud Carlos III