TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway
TMAO promotes the methylation level of the <i>CYTB</i> gene promoter and down-regulates the expression of CYTB by inhibiting the expression of TET2. The decreased expression level of CYTB induces ROS, promoting VECs pyroptosis.
Authors
- Linzhen Xia (ORCID: https://orcid.org/0000-0002-9739-6958)
- Xiangyu Chen (ORCID: https://orcid.org/0000-0002-4284-8507)
- Zuo Wang
Institutions
- Hunan Normal University (CN)
- Changsha Hospital for Maternal and Child Health Care (CN)
- Hunan Provincial Maternal and Child Health Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2147/jir.s527437
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Hunan Normal University
- University of South China