Development and Preparation of the Composition and Technology of Phytosomal Gel for the Treatment of Coupe Rose and Study of Quality Criteria

Coupe rose is a widespread chronic skin problem.In the treatment of the disease, many synthetic and Phyto preparations are applied.However, the solution of the problem requires new drug delivery systems-phytosomes, which are more effective, with a reduced bioavailability and a long-term effect.Taking this into account, a scientifically based photocomposition of optimal composition was compiled from horse chestnutordinary hops-green tea plants, a phytoextract was obtained on its basis and the technology of obtaining a Phyto some was implemented.On the basis of phytoextract and phosphatidylcholine in a 1:1 vacuum-evaporative device (BioBase brand, 2 hours, temperature regime 40-50, rotation speed of the device 120 RPM) by rotor evaporation method, optimal composition Phyto some was obtained.The optimal composition of Phyto some was included in various gel bases, the optimal composition on the basis of xanthan gum (Phyto some, xanthan gum, Phenoxyethanol + Ethylhexylglycerin, Pentylene glycol, vitamin E, rose oil, distilled water) was determined.In the centrifuge of the brand "Tablet top DSC 200A-2, speed-6000 rpm " it was found that it remains stable at 6000 rpm for 10 min, pH indicator -6.4,characteristic of good diffusion and absorbability.Ex vivo studies calculated the amount of rutin released from phytosomal gel within 24 hours and determined to be 85%.The gel "Anti coupe rose Phyto Som" developed during the studies was microbiologically pure; it was found that it has an Angio protective effect in comparison with the gel "Troxevazin" in Chinchilla rabbits.