Development of the Composition and Production Technology of Floating Tablets Against Helicobacter Pylori and Determination of Quality Criteria

Despite the fact that a large number of synthetic drugs are currently used to prevent Helicobacter pylori infection, the problem remains relevant.The development of the technology of floating tablets of plant origin is important and significant in preventing the complications caused by the infection.Floating tablets are new drug delivery systems that allow the release of active substances intermittently by keeping them in the gastric environment for a long time.For this purpose, a Phyto composition with an optimal composition of garlic, black cumin, and ginger plants in a ratio of 7:2:1 against gastrointestinal infection Helicobacter pylori was formulated in the Pharmaceutical Technology Laboratory of the Azerbaijan Medical University and a phytoextract was prepared based on it.It was determined that the extraction method -high-speed extraction; device rotation speed -3300 rpm; solvent -90% ethyl alcohol; exposure time -7 min; temperature regime -25C; pH -6.5; density -0.823 g/cm3; when the maximum biologically active substances are 2.5%.This optimal composition had a positive sensitivity to Helicobacter pylori.The technology of floating tablets based on the developed phytoextract (phytoextract, Carbopol, xanthan gum, microcrystalline cellulose, sodium bicarbonate, lactose, magnesium stearate, Aerosol, rosemary aromatic water; gelatin-microcrystalline cellulose-rosemary aromatic water for the coating) was developed and the quality criteria were studied: average weight -0.7g, compressive strength -7.0 0.51 Pa, thickness -4.21 0.23 mm, diameter -11.20 0.26mm, floating ability: for a regular tablet -5 min, for a coated tablet -14 min.The release of biologically active substances from floating tablets was proven by ex vivo studies, and the amount of BFM diffusing into a buffer solution (pH-1-2) within 12 hours was 95.58 1.20%.The phytoextract and floating tablet were tested for microbial contamination and proved to be clean during microbiological tests.