Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study

Our results suggest associations between EAT thickness, increased LV wall thickness, LA size, and decreased mitral annular velocity in early adulthood. The observed alterations in these specific cardiac metrics are particularly known as early structural alterations linked with obesity-related LV concentric remodeling and relaxation abnormalities. Thus, EAT may contribute in cardiac subclinical remodelling initiating in early adulthood, which may lead to various cardiovascular outcomes later in life. However, due to the modest effect sizes observed, further studies are required to assess the magnitude of these associations over long-term follow-up.

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Publication Details

Journal
European Journal of Preventive Cardiology
Published
2025-07-01
DOI
https://doi.org/10.1093/eurjpc/zwaf394
Citations
2
Primary Topic
Cardiovascular Disease and Adiposity
Type
article
Field-Weighted Citation Impact
2.78
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article

Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study

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2 citations
European Journal of Preventive Cardiology
Cardiovascular Disease and Adiposity
2.78
article

Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study

Eero Jokinen, Päivi Tossavainen, Juha Mykkänen, Saku Ruohonen, Mika A. P. Kähönen, Suvi Rovio, B. Gustafsson, Olli Tuomas Raitakari, Tomi P Laitinen, Jorma S.A. Viikari, Katja Pahkala, Terho J. Lehtimäki
article en
2 citations

Abstract

Our results suggest associations between EAT thickness, increased LV wall thickness, LA size, and decreased mitral annular velocity in early adulthood. The observed alterations in these specific cardiac metrics are particularly known as early structural alterations linked with obesity-related LV concentric remodeling and relaxation abnormalities. Thus, EAT may contribute in cardiac subclinical remodelling initiating in early adulthood, which may lead to various cardiovascular outcomes later in life. However, due to the modest effect sizes observed, further studies are required to assess the magnitude of these associations over long-term follow-up.

European Journal of Preventive Cardiology
University of Helsinki (FI), University of Turku (FI), Tampere University (FI), University of Eastern Finland (FI), Oulu University Hospital (FI), Helsinki University Hospital (FI), Turku University Hospital (FI), Kuopio University Hospital (FI), Tampere University Hospital (FI), Tampere University (FI), Fimlab (Finland) (FI), Orion Corporation (United Kingdom) (GB), University of Oulu (FI)
Good health and well-being
Openalex Percentile: Top 9%
Cardiovascular Disease and Adiposity
2.78
DOIOpen Access PDFOpenAlex
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