Identification of Crucial Genes Associated With MYCN‐Driven Neuroblastoma Based on Single‐Cell Analysis and Machine Learning
Our results provide molecular insights into the transcriptional changes associated with MYCN amplification in NB. In particular, the identification of CKB and PCSK1N suggests their potential role in driving tumor progression, making them promising targets for novel treatments in MYCN-driven NB.
Authors
- Dedong Zhang
- Jiasi Zhang (ORCID: https://orcid.org/0000-0001-9442-2009)
- Siying Liu (ORCID: https://orcid.org/0000-0002-0591-0906)
- Yaqin Wang (ORCID: https://orcid.org/0000-0003-3397-3071)
- Yichen Lei
- Aiguo Liu (ORCID: https://orcid.org/0000-0002-8541-1671)
- Yu Wen (ORCID: https://orcid.org/0000-0002-4413-2115)
- Yongbing Zhu
- Xiaoyan Zhao
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/cam4.71008
- Citations
- 2
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Huazhong University of Science and Technology