Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction

Authors

Fuhao Zhang (ORCID: https://orcid.org/0009-0001-4336-431X)
Min Zeng (ORCID: https://orcid.org/0000-0002-1726-0955)
Ruiqing Zheng (ORCID: https://orcid.org/0000-0001-6372-6798)
Yidong Hou (ORCID: https://orcid.org/0000-0002-6983-3700)
Yiming Li (ORCID: https://orcid.org/0000-0003-4602-3905)
Min Li (ORCID: https://orcid.org/0000-0003-3518-683X)
Fei Guo (ORCID: https://orcid.org/0000-0003-2911-7643)

Institutions

Central South University (CN)
North West Agriculture and Forestry University (CN)
Northwest A&F University (CN)

Publication Details

Journal: Bioinformatics
Published: 2025-07-01
DOI: https://doi.org/10.1093/bioinformatics/btaf385
Citations: 5
Primary Topic: CRISPR and Genetic Engineering
Type: article
Field-Weighted Citation Impact: 4.03

Funders

National Natural Science Foundation of China
Central South University
Natural Science Foundation of Hunan Province
National Key Research and Development Program of China

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article

Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction

Fuhao Zhang, Min Zeng, Ruiqing Zheng, Yidong Hou et al.

Jul 1, 2025

5 citations

Bioinformatics

CRISPR and Genetic Engineering

4.03

article

Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction

Fuhao Zhang, Min Zeng, Ruiqing Zheng, Yidong Hou, Yiming Li, Min Li, Fei Guo

July 1, 2025article en

5 citations

Abstract

No abstract available for this paper.

BioinformaticsVol. 41(7)

Central South University (CN), North West Agriculture and Forestry University (CN), Northwest A&F University (CN)

National Natural Science Foundation of China, Central South University, Natural Science Foundation of Hunan Province, National Key Research and Development Program of China

Openalex Percentile: Top 6%

CRISPR and Genetic Engineering

4.03

DOI Open Access PDF OpenAlex

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Leveraging protein language models for cross-variant CRISPR/Cas9 sgRNA activity prediction — Fuhao Zhang, Min Zeng, et al. · Bioinformatics (2025) | TGRS Research Map | TGRS