Structural Model of the Oncostatin M (OSM)-OSMRβ-gp130 TernaryComplex Reveals Pathways of Allosteric Communication in OSMSignaling
The findings of this study not only enhance the mechanistic understanding of OSM binding to the heteromeric OSMRβ/gp130 but also identify druggable binding sites for structure-based design of small molecules to inhibit the intracellular signal transduction.
Authors
- Weiwei Xue (ORCID: https://orcid.org/0000-0002-3285-0574)
- Ding Luo (ORCID: https://orcid.org/0009-0000-9326-319X)
- Qian Yan (ORCID: https://orcid.org/0000-0003-4809-2680)
- Qingqing Du
Institutions
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2174/0109298673362742250508113436
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05