Network Pharmacology and Validation Experiments Reveal Cryptotanshinone Inhibits Acute Myeloid Leukemia Progression by Activating Endoplasmic Reticulum Stress
This study indicates that CTS inhibits AML cell proliferation and induces apoptosis while activating the ERS signaling pathway. However, aberrant activation of the Hippo-YAP pathway weakens this effect. These findings provide novel theoretical insights into potential therapeutic strategies for AML.
Authors
- Xiang Yao
- Yan Huang (ORCID: https://orcid.org/0000-0001-7607-9585)
- Rongrong Liu (ORCID: https://orcid.org/0000-0003-2722-578X)
- Jie Wei (ORCID: https://orcid.org/0009-0000-7600-8779)
- Guan-ye Nai
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-07-01
- DOI
- https://doi.org/10.2174/0109298673348269250611042934
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00