SYNTHESIS, ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF COORDINATION COMPOUNDS OF COPPER (II) WITH A THIOSEMICARBAZONE CONTAINING AN ACETANILIDE FRAGMENT

The synthesis of novel antibiotic compounds is a significant area of modern research. This paper describes a method for synthesizing a thiosemicarbazone containing the acetanilide fragment, as well as coordination compounds based on it. The structure of the thiosemicarbazone was confirmed using 1H and 13C NMR spectroscopy, while the structure of the coordination compounds was indirectly confirmed through FTIR spectroscopy and elemental metal analysis. Biological investigations revealed that compounds [Cu(H2O)(HL)Br] and [Cu(H2O)(HL)NO3] exhibit 38 times and 19 times better antimicrobial activity against Staphylococcus aureus and Bacillus cereus, respectively, compared to Furacin.