The XPO1 Inhibitor Eltanexor Modulates the Wnt/β-Catenin Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
In this study, we show the XPO1 inhibitor eltanexor acts as an effective colorectal cancer chemopreventive agent both in vivo and in vitro. This occurs by reducing COX-2 expression by modulating the Wnt/β-catenin signaling pathway. Collectively, these findings highlight XPO1 as a potent target for colorectal cancer chemoprevention.
Authors
- Anup Kasi (ORCID: https://orcid.org/0000-0002-4305-5701)
- Dan A. Dixon (ORCID: https://orcid.org/0000-0001-5631-4365)
- Andrew E. Evans (ORCID: https://orcid.org/0009-0005-3283-2148)
- Sahida Afroz
- Alexa Magstadt
Institutions
- University of Kansas (US)
- The University of Kansas Cancer Center (US)
- University of Kansas Medical Center (US)
- Winthrop Rockefeller Foundation (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0052
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00