Vanishing bone disease-like presentation in a middle-aged male due to primary hyperparathyroidism: A rare presentation

Vanishing bone disease (VBD), also known as Gorham-Stout disease, is typically idiopathic and characterized by progressive osteolysis. However, secondary causes mimicking VBD-like bone loss must be considered, especially in adults. We present a rare case of a 46-year-old male with progressive femoral osteolysis and renal calculi, ultimately diagnosed with primary hyperparathyroidism (PHPT) due to a parathyroid adenoma. Following parathyroidectomy surgery value of parathyroid hormone (PTH) reduced significantly and patient improved clinically. This case highlights the importance of metabolic and endocrine evaluation in osteolytic conditions and demonstrates a reversible form of “vanishing” bone loss.