Gut microbiome compositional and functional features associate with Alzheimer's disease pathology
Gut microbiome composition and function differ between people with Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Co-occurring gut microbes show differential abundance across AD-related groups (AD vs CU, amyloid status+ vs amyloid status-, and apolipoprotein E (APOE) ε4 status+ vs APOE ε4 status-). Gut microbiome composition also differs between people with AD dementia and CU individuals in a larger validation cohort. Differentially abundant gut microbiome composition and function between AD and CU groups are correlated with cerebrospinal fluid biomarkers for AD and related pathologies.
Authors
- Colette Blach (ORCID: https://orcid.org/0000-0003-1264-0614)
- Margo B. Heston (ORCID: https://orcid.org/0000-0002-0980-2275)
- MacKenzie Bryant (ORCID: https://orcid.org/0000-0003-0749-2995)
- Tyler K. Ulland
- Federico E. Rey (ORCID: https://orcid.org/0000-0002-0239-7780)
- Lora A. Khatib (ORCID: https://orcid.org/0000-0002-6998-8278)
- Daniel T. McDonald (ORCID: https://orcid.org/0000-0003-0876-9060)
- Robert J. Knight (ORCID: https://orcid.org/0000-0001-9927-6354)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Rima F Kaddurah-Daouk (ORCID: https://orcid.org/0000-0003-1858-5732)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Jea Woo Kang (ORCID: https://orcid.org/0000-0003-1202-4432)
- Leyla Schimmel
- Jennifer S. Labus (ORCID: https://orcid.org/0000-0002-6634-2551)
- Amanda Hazel Dilmore (ORCID: https://orcid.org/0000-0001-6493-7116)
- Yuetiva Deming
- Nathaniel A. Chin (ORCID: https://orcid.org/0000-0001-8008-9356)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Antonio González (ORCID: https://orcid.org/0000-0002-5900-3965)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Cynthia M. Carlsson
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- Duke University (US)
- Sahlgrenska University Hospital (SE)
- University of California San Diego (US)
- Center for Neurologic Study (US)
- UK Dementia Research Institute (GB)
- La Jolla Bioengineering Institute (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70417
- Citations
- 9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Cure Alzheimer's Fund
- Vetenskapsrådet
- National Institutes of Health
- National Institute on Aging