Impact of Alzheimer's disease on sleep in adults with Down syndrome
Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.
Authors
- Laia Ribas (ORCID: https://orcid.org/0000-0001-5538-6236)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Bessy Benejam (ORCID: https://orcid.org/0000-0002-6789-8615)
- Ricardo S. Osorio (ORCID: https://orcid.org/0000-0002-2735-9609)
- Íñigo Rodríguez‐Baz (ORCID: https://orcid.org/0000-0003-3039-9115)
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Esther Blessing (ORCID: https://orcid.org/0000-0002-7961-8844)
- Lídia Vaqué‐Alcázar (ORCID: https://orcid.org/0000-0002-6776-6559)
- Ana Carolina Bueno (ORCID: https://orcid.org/0000-0001-9043-9831)
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- Sára E. Zsadanyi (ORCID: https://orcid.org/0000-0002-2033-5989)
- Anne‐Sophie Rebillat (ORCID: https://orcid.org/0000-0003-1995-9177)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Nuole Zhu (ORCID: https://orcid.org/0000-0002-0015-9455)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Lucía Maure-Blesa (ORCID: https://orcid.org/0000-0001-5643-7971)
- Sandra Giménez (ORCID: https://orcid.org/0000-0001-8031-2319)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Alejandra O. Morcillo‐Nieto (ORCID: https://orcid.org/0000-0003-2202-3521)
- Christos Panagiotis Lisgaras (ORCID: https://orcid.org/0000-0003-3712-5993)
- Susana Fernández (ORCID: https://orcid.org/0000-0003-4154-682X)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Daniel Alcolea
- Alberto Lleó
Institutions
- Universitat Autònoma de Barcelona (ES)
- Nathan Kline Institute for Psychiatric Research (US)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- NYU Langone Health (US)
- New York State Office of Mental Health (US)
- Fondation Jérôme-Lejeune (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1002/alz.70400
- Citations
- 1
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Jerome Foundation
- Fondation Jérôme Lejeune
- Global Brain Health Institute
- European Commission
- Fondation Jérôme Lejeune
- Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España
- Fundación Tatiana Pérez de Guzmán el Bueno
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- National Institutes of Health
- Horizon 2020 Framework Programme
- Instituto de Salud Carlos III
- European Regional Development Fund
- National Institute on Aging
- H2020 European Institute of Innovation and Technology