Transition Metal-Catalyzed Asymmetric Carboxylation with CO<sub>2</sub>

Optically active carboxylic acid derivatives are important in the field of medicinal chemistry and pharmaceuticals. Preparation of these chiral carboxylic acids from naturaly abundant CO2 would be highly valuable, however, the synthetic methodologies have been limited. Transition metal-catalyzed asymmetric synthesis has opened a new window for the direct access to enantio-enriched carboxylic acid derivatives. Herein, recent processes of transition metal-catalyzed asymmetric carboxylation reactions will be discussed.