Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma

This study supports further investigation into targeting of CDKs and cyclins in select sarcoma subtypes, and it specifically suggests a therapeutic approach inhibiting CDK7 in chordoma.

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Publication Details

Journal
JCO Precision Oncology
Published
2025-07-01
DOI
https://doi.org/10.1200/po-25-00149
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma

Daniel Hübschmann, Wei Jiang, Stefan Fröhling, Jaime F. Modiano et al.
JCO Precision Oncology
Sarcoma Diagnosis and Treatment
article

Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma

Daniel Hübschmann, Wei Jiang, Stefan Fröhling, Jaime F. Modiano, Caitlin M. King, Sosipatros A. Boikos, Daniel S. Lefler, Daniel M. Freed, Andrew Elliott, Matthew James Oberley, Atrayee Basu Mallick, Hanno Glimm, Jude Al-Sabah, Robert G. Maki, Richard F. Riedel, Ubaldo Martinez‐Outschoorn
article en

Abstract

This study supports further investigation into targeting of CDKs and cyclins in select sarcoma subtypes, and it specifically suggests a therapeutic approach inhibiting CDK7 in chordoma.

JCO Precision OncologyVol. 9(9)
University of Minnesota (US), Memorial Sloan Kettering Cancer Center (US), Thomas Jefferson University (US), German Cancer Research Center (DE), Heidelberg University (DE), Thomas Jefferson University Hospital (US), Helmholtz-Zentrum Dresden-Rossendorf (DE), University Hospital Heidelberg (DE), Chordoma Foundation (US), National Center for Tumor Diseases (DE), Duke Medical Center (US), Caris Life Sciences (United States) (US), DKFZ-ZMBH Alliance (DE), Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE), Boehringer Ingelheim (United States) (US), University Hospital Carl Gustav Carus (DE), Deutsches Konsortium für Translationale Krebsforschung (DE), University of Pennsylvania (US)
Openalex Percentile: Top 74%
Sarcoma Diagnosis and Treatment
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