Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma
This study supports further investigation into targeting of CDKs and cyclins in select sarcoma subtypes, and it specifically suggests a therapeutic approach inhibiting CDK7 in chordoma.
Authors
- Daniel Hübschmann (ORCID: https://orcid.org/0000-0002-6041-7049)
- Wei Jiang (ORCID: https://orcid.org/0000-0001-5184-3233)
- Stefan Fröhling (ORCID: https://orcid.org/0000-0001-7907-4595)
- Jaime F. Modiano (ORCID: https://orcid.org/0000-0001-6398-7648)
- Caitlin M. King (ORCID: https://orcid.org/0000-0001-6305-9331)
- Sosipatros A. Boikos (ORCID: https://orcid.org/0000-0002-8608-6962)
- Daniel S. Lefler (ORCID: https://orcid.org/0000-0001-8051-8800)
- Daniel M. Freed (ORCID: https://orcid.org/0000-0002-3564-6376)
- Andrew Elliott (ORCID: https://orcid.org/0000-0001-8494-8031)
- Matthew James Oberley (ORCID: https://orcid.org/0000-0001-6419-2513)
- Atrayee Basu Mallick (ORCID: https://orcid.org/0000-0003-2490-3004)
- Hanno Glimm (ORCID: https://orcid.org/0000-0003-4104-1135)
- Jude Al-Sabah (ORCID: https://orcid.org/0000-0003-2635-0423)
- Robert G. Maki (ORCID: https://orcid.org/0000-0002-9853-2528)
- Richard F. Riedel (ORCID: https://orcid.org/0000-0001-5412-8710)
- Ubaldo Martinez‐Outschoorn (ORCID: https://orcid.org/0000-0003-1483-4551)
Institutions
- University of Minnesota (US)
- Memorial Sloan Kettering Cancer Center (US)
- Thomas Jefferson University (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Thomas Jefferson University Hospital (US)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Chordoma Foundation (US)
- National Center for Tumor Diseases (DE)
- Duke Medical Center (US)
- Caris Life Sciences (United States) (US)
- DKFZ-ZMBH Alliance (DE)
- Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE)
- Boehringer Ingelheim (United States) (US)
- University Hospital Carl Gustav Carus (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1200/po-25-00149
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00