Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk
PGS complements FH and PVs of LS genes in predicting CRC risk and improves prediction performance beyond traditional genetic factors across diverse populations.
Authors
- Alan R. Sanders (ORCID: https://orcid.org/0000-0001-6629-4011)
- Henry M. Dunnenberger
- Ashley Mulford
- Zhuqing Shi (ORCID: https://orcid.org/0000-0001-6321-950X)
- Andrew S. Rifkin (ORCID: https://orcid.org/0009-0004-9038-7014)
- Jun Wei (ORCID: https://orcid.org/0000-0002-8234-4741)
- S. Lilly Zheng (ORCID: https://orcid.org/0009-0005-3514-2468)
- David Duggan
- Peter J. Hulick (ORCID: https://orcid.org/0000-0001-8397-4078)
- Allison DePersia (ORCID: https://orcid.org/0000-0001-8338-3112)
- Jianfeng Xu (ORCID: https://orcid.org/0000-0002-9419-6627)
- Brian T. Helfand (ORCID: https://orcid.org/0000-0002-7707-3318)
- Annabelle Ashworth
- Chi-Hsiung Wang
- Huy Tran (ORCID: https://orcid.org/0009-0006-1648-3280)
- Talia Y. Helfand
Institutions
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- NorthShore University HealthSystem (US)
- University of Chicago (US)
- City of Hope (US)
- Genomic Health (United States) (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-07-01
- DOI
- https://doi.org/10.1200/po-25-00081
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.94