Formulation Optimization and Characterization of Transdermal Patches of Luliconazole and Posaconazole by Response Surface Methodology

In the present study the transdermal drug delivery system of two anti-fungal drugs i.e., luliconazole and posaconazole was reported using surface response method. Independent variable like HPMC, E-5 and PEG and dependent variable i.e., folding endurance and in vitro release study were taken in consideration. 15 formulations having varying concentration of polymers and permeation enhancer were formulated using solvent casting method. Results indicates that R1 (folding endurance) and R2 (% drug released) ranged from 62 to 88 and 76.22 to 92.46 %. Validated values were found to be much closed to the optimized values and results were closed to the selected batches as obtained by the software’s.