Development of AuNPs-Based Gel: Physicochemical Properties, Antibacterial Activity, and Skin Permeation Studies

Gold nanoparticles (AuNPs) have raise as versatile agents in biosciences applications due to their exclusive physicochemical nature. principle of this investigation is to formulate and test a gel containing AuNPs that uses Carbopol 934 as its gelling agent. To optimise the medicinal and rheological qualities, gels were made using different concentrations of carbopol (0.5%, 1.0%, 1.5%, and 2.0%), along with various excipients such as triethanolamine and black cumin oil. The physicochemical properties of the gels were assessed, including their homogeneity, transparency, pH, spreadability, viscosity, medication concentration, and ability to gel. Effective drug delivery was demonstrated in ex vivo skin permeation and deposition tests utilising rat abdomen skin. In comparison to commercial formulations, the AuNPs gel demonstrated substantial zones of inhibition when tested against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (PA), and Staphylococcus aureus (SA),. The formulations were found to be safe in skin irritancy testing. The outcomes of this study display that AuNPs gels have great promise as a safe and effective vehicle for transdermal drug administration with improved therapeutic efficacy and less discomfort.