Studies on Spectral Characterization, Dissolution and Solubility of Aceclofenac Multicomponent Inclusion Complex using Different Auxiliary Agent

Current research was designed to examine how aceclofenac interacted with cyclodextrin and its derivatives. The different auxiliary agents such as mannitol, L-arginine and citric acid were also evaluated for enhancement solubility of aceclofenac and selected as third component for preparing multicomponent inclusion complex. In direction to increase bioavailability and solubility of the poorly soluble medication aceclofenac, a complex was created that belongs to BCS CLASS-II. The multicomponent inclusion complex was created by using physical mixing and kneading techniques. The distinct concentrations of L-arginine were tested for the ternary systems. Interactions between the solid and liquid phases were studied using FTIR, DSC, XRD, and 1H-NMR. A study on phase solubility proved that L-arginine significantly affected the methyl-β-cyclodextrin complexation with aceclofenac. Saturation solubility study and in-vitro study state that prepared complex shows expansion of solubility similarly bioavailability of poorly water-soluble aceclofenac