Development and Evaluation of a Topical Gel Containing 0.1% Adapalene and 2.5% Benzoyl Peroxide for Acne Treatment

The gel product that combines two active ingredients adapalene (AD) and benzoyl peroxide (BO) has been used for a long time with good acne effectiveness and is licensed in the treatment of moderate to severe acne. On the market today, there are a few acne products containing these two active ingredients, however, the formula and preparation process have not been announced. Therefore, the study was conducted to research and prepare a gel product that combines AD 0.1% and BO 2.5%. The study results show that the gel formulation uses excipients Simugel SMS88 (6%), propylene glycol (4%), glycerin (4%), sodium docusate (0.05%), poloxamer 188 (0.2%). ) and demineralized water (83.15%) for a soft, pleasant physical sensation when applied, equivalent to a famous product (named X, which has the same ingredients and contents) in terms of parameters such as thinness, release of active ingredients, in vitro permeability . The results of stability monitoring under accelerated conditions for 6 months showed that the gel product had no significant physical or chemical changes. The research has successfully built the formula and process of preparing a gel product that combines the two active ingredients. The research results can be applied in upgrading larger batch sizes and deployed in production in the future.