Extraction of Chinese Green Tea and its Toxicological Evaluation

Green tea extract has numerous health benefits along with anticancer activity due to the presence of powerful antioxidants, but there are some controversial adverse effects, in the case of long-term treatment as well as dose dependent. This study focused on the identification and content of bioactive components of Chinese green tea extract and investigated their toxicological effect on the pathological and histological of rats. The study was designed for an acute dose of 2000 mg/kg green tea extract for seven days. Sub-acute doses of 300 mg/kg, 500 mg/kg, and 1000 mg /Kg for 28 male and female BN rats. Results demonstrated that all rats were alive, and biochemical parameters met the reference values. Slight histopathological changes were observed in the liver at a dose of 1000 mg/kg. These findings suggest that the loading dose did not affect the vital organs of the rats or their survival rate. This Chinese green tea extract can be used to achieve the expected therapeutic benefits without any adverse effects.