Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan
Orthohantavirus infection is a zoonotic disease transmitted to humans through contact with infected rodents. In Eurasia, Old World Orthohantaviruses can cause haemorrhagic fever with renal syndrome (HFRS), while in the Americas, New World Orthohantaviruses are responsible for hantavirus cardiopulmonary syndrome (HCPS). In Kazakhstan, the first recorded cases of HFRS appeared in the West Kazakhstan region in 2000, which has since then been established as an endemic area due to the presence of stable rodent reservoirs and recurring human infections. Routine diagnosis of HFRS in this region relies primarily on immunoassays. To enhance diagnostic precision, we aimed to implement both serological and molecular methods on samples from suspected HFRS cases in the endemic West Kazakhstan region and non-endemic Almaty City. A total of 139 paired serum, saliva, and urine samples were analysed using IgM/IgG ELISA, immunoblot assays, and qPCR. Our findings confirm that suspected HFRS cases in West Kazakhstan are associated with the Puumala virus serotype.
Authors
- Guenter Froeschl (ORCID: https://orcid.org/0000-0003-2743-7555)
- Nurbek Maikanov
- Lyazzat Yeraliyeva (ORCID: https://orcid.org/0000-0002-0892-166X)
- Sandra Eßbauer (ORCID: https://orcid.org/0000-0003-0909-742X)
- Abhishek Bakuli (ORCID: https://orcid.org/0000-0001-5123-1974)
- Nur B. Tukhanova (ORCID: https://orcid.org/0000-0002-6514-3745)
- Zauresh B. Zhumadilova (ORCID: https://orcid.org/0009-0002-7489-2737)
- Lukas Peintner (ORCID: https://orcid.org/0000-0002-0445-1445)
- Edith Wagner (ORCID: https://orcid.org/0000-0003-1720-3923)
- G.Zh. Tokmurziyeva
- Anna Shin (ORCID: https://orcid.org/0000-0001-9911-8233)
Institutions
- University of Freiburg (DE)
- Al-Farabi Kazakh National University (KZ)
- Kazakh National Medical University (KZ)
- Kazakh Research Institute of Plant Protection and Quarantine (KZ)
- Kazakh Institute of Oncology and Radiology (KZ)
- Jena University Hospital (DE)
- Bundeswehr Medical Service Academy (DE)
- Institut für Mikrobiologie der Bundeswehr
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Viruses
- Published
- 2025-06-28
- DOI
- https://doi.org/10.3390/v17070925
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutscher Akademischer Austauschdienst
- Bundesministerium für Wirtschaftliche Zusammenarbeit und Entwicklung
- Center for International Health