Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats.
HDAC3 plays a role in rats' complex pathogenesis of SBI. HDAC3 inhibition imparts a protective role in early brain injury in SBI in rats by regulating autophagy and inflammation via up-regulation of Npas4.
Authors
- Hongfei Zhu (ORCID: https://orcid.org/0000-0002-1530-9129)
- Haiping Gu (ORCID: https://orcid.org/0009-0009-3555-9086)
- Baoqi Dang (ORCID: https://orcid.org/0000-0002-5763-9628)
- Mengying Shi
- Yating Gong
- Yi Sun (ORCID: https://orcid.org/0000-0002-0210-4730)
- Jiejie Yu
- Muyao Wu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.80235.17372
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China